Friday, March 7, 2008

Tuberculosis Risks For Health Workers In Developing Countries

Latent infection with tuberculosis is common and some infected people develop the active form of the disease. Health-care workers (HCWs) can become infected, develop active disease, and can pass their infection on to patients and others. Research published in PLoS Medicine shows that HCWs in developing countries are at particularly high risk. Over half were found to have latent TB.

One third of the world's population is infected with Mycobacterium tuberculosis, the bacterium that causes TB. In most people, the bug causes no health problems and it remains latent. But about 10% of infected people develop active, potentially fatal TB disease, most commonly in their lungs. More than 90% of the world's cases of TB occur in low- and middle-income countries. The researchers Rajnish Joshi at University of California Berkeley and colleagues conducted a systematic review, which involved a comprehensive search for studies that had collected data on TB infection in health-care workers in these countries. Averaged out over the 51 studies which they found, 54% of health workers had latent TB. The TB disease rates in health-care workers were also substantially higher than those in the general population of the same countries.

In high-income countries, measures are in place to reduce the TB infection risk faced by health workers. In contrast, most of the hospitals in the studies found by the researchers reported no or minimal TB control measures. The researchers say that research is needed to establish whether the control measures that have reduced TB transmission to health workers in high-income countries will work elsewhere, and whether they will be affordable.

"Tuberculosis among health-care workers in low- and middle-income countries: A systematic review"
Joshi R, Reingold AL, Menzies D, Pai M
(2006) PLoS Med 3(12): e494.
LINK TO ARTICLE ONLINE

About PLoS Medicine

PLoS Medicine is an open access, freely available international medical journal. It publishes original research that enhances our understanding of human health and disease, together with commentary and analysis of important global health issues. For more information, visit http://www.plosmedicine.org

About the Public Library of Science

The Public Library of Science (PLoS) is a non-profit organization of scientists and physicians committed to making the world's scientific and medical literature a freely available public resource. For more information, visit http://www.plos.org

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